EC 3.1.8.1 - Aryldialkylphosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.8.1

Names

Accepted name:
aryldialkylphosphatase
Other names:
A-esterase
OPA anhydrase
OPH
aryltriphosphatase
esterase B1
esterase E4
organophosphate esterase
organophosphate hydrolase
organophosphorus acid anhydrase
organophosphorus hydrolase
paraoxon esterase
paraoxon hydrolase
paraoxonase
phosphotriesterase
pirimiphos-methyloxon esterase
Systematic name:
aryltriphosphate dialkylphosphohydrolase

Reaction

Cofactor

Comments:

Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC01026
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004063
CAS Registry Number: 117698-12-1
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Aldridge, W.N.
    Serum esterases. I. Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate and a method for their determination.
    Biochem. J. 53: 110-117 (1953). [PMID: 13032041]
  2. Bosmann, H.B.
    Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
    Biochim. Biophys. Acta 276: 180-191 (1972). [PMID: 5047702]
  3. Mackness, M.I., Thompson, H.M., Hardy, A.R. and Walker, C.H.
    Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
    Biochem. J. 245: 293-296 (1987). [PMID: 2822017]
  4. Main, A.R.
    The differentiation of the A-type esterases in sheep serum.
    Biochem. J. 75: 188-195 (1960). [PMID: 14420012]
  5. In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.) Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood Ltd., Chichester, UK, 1989

[EC 3.1.8.1 created 1989]