EC 3.1.7.9 - Isotuberculosinol synthase

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IntEnz Enzyme Nomenclature
EC 3.1.7.9

Names

Accepted name:
isotuberculosinol synthase
Other name:
Rv3378c
Systematic name:
tuberculosinyl diphosphate diphosphohydrolase (isotuberculosinol forming)

Reactions

Comments:

Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives tuberculosinol in 1:1 mixture, cf EC 3.1.7.8, tuberculosinol synthase. The isotuberculosinol form was a 3:1 mixture of the 13S and 13R forms, respectively.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Nakano, C., Ootsuka, T., Takayama, K., Mitsui, T., Sato, T., Hoshino, T.
    Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R, S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
    Biosci. Biotechnol. Biochem. 75: 75-81 (2011). [PMID: 21228491]
  2. Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y., Hara, T.
    Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
    Org. Biomol. Chem. 9: 2156-2165 (2011). [PMID: 21290071]

[EC 3.1.7.9 created 2011]