EC - Tuberculosinol synthase

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IntEnz Enzyme Nomenclature


Accepted name:
tuberculosinol synthase
Other name:
Systematic name:
tuberculosinyl diphosphate diphosphohydrolase (tuberculosinol forming)



Only found in species of Mycobacterium that cause tuberculosis. In addition, it also gives isotuberculosinol in 1:1 mixture, cf. EC, isotuberculosinol synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Nakano, C., Ootsuka, T., Takayama, K., Mitsui, T., Sato, T., Hoshino, T.
    Characterization of the Rv3378c gene product, a new diterpene synthase for producing tuberculosinol and (13R,S)-isotuberculosinol (nosyberkol), from the Mycobacterium tuberculosis H37Rv genome.
    Biosci. Biotechnol. Biochem. 75 : 75-81 (2011). [PMID: 21228491]
  2. Hoshino, T., Nakano, C., Ootsuka, T., Shinohara, Y., Hara, T.
    Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophage phagocytosis.
    Org. Biomol. Chem. 9 : 2156-2165 (2011). [PMID: 21290071]

[EC created 2011]