EC - S-sulfosulfanyl-L-cysteine sulfohydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
S-sulfosulfanyl-L-cysteine sulfohydrolase
Other name:
Systematic name:
[SoxY protein]-S-sulfosulfanyl-L-cysteine sulfohydrolase




Contains Mn2+. The enzyme is part of the Sox enzyme system, which participates in a bacterial thiosulfate oxidation pathway that produces sulfate. It catalyses two reactions in the pathway. In both cases the enzyme hydrolyses a sulfonate moiety that is bound (either directly or via a sulfane) to a cysteine residue of a SoxY protein, releasing sulfate. The enzyme from Paracoccus pantotrophus contains a pyroglutamate (cycloglutamate) at its N-terminus.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Quentmeier, A., Friedrich, C. G.
    The cysteine residue of the SoxY protein as the active site of protein-bound sulfur oxidation of Paracoccus pantotrophus GB17.
    FEBS Lett. 503 : 168-172 (2001). [PMID: 11513876]
  2. Friedrich, C. G., Rother, D., Bardischewsky, F., Quentmeier, A., Fischer, J.
    Oxidation of reduced inorganic sulfur compounds by bacteria: emergence of a common mechanism?
    Appl. Environ. Microbiol. 67 : 2873-2882 (2001). [PMID: 11425697]
  3. Quentmeier, A., Hellwig, P., Bardischewsky, F., Grelle, G., Kraft, R., Friedrich, C. G.
    Sulfur oxidation in Paracoccus pantotrophus: interaction of the sulfur-binding protein SoxYZ with the dimanganese SoxB protein.
    Biochem. Biophys. Res. Commun. 312 : 1011-1018 (2003). [PMID: 14651972]
  4. Epel, B., Schafer, K. O., Quentmeier, A., Friedrich, C., Lubitz, W.
    Multifrequency EPR analysis of the dimanganese cluster of the putative sulfate thiohydrolase SoxB of Paracoccus pantotrophus.
    J. Biol. Inorg. Chem. 10 : 636-642 (2005). [PMID: 16133204]
  5. Hensen, D., Sperling, D., Truper, H. G., Brune, D. C., Dahl, C.
    Thiosulphate oxidation in the phototrophic sulphur bacterium Allochromatium vinosum.
    Mol. Microbiol. 62 : 794-810 (2006). [PMID: 16995898]
  6. Grabarczyk, D. B., Berks, B. C.
    Intermediates in the Sox sulfur oxidation pathway are bound to a sulfane conjugate of the carrier protein SoxYZ.
    PLoS ONE 12 : e0173395 (2017). [PMID: 28257465]

[EC created 2018]