EC - 3',5'-cyclic-AMP phosphodiesterase

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IntEnz Enzyme Nomenclature


Accepted name:
3',5'-cyclic-AMP phosphodiesterase
Other names:
cAMP-specific phosphodiesterase
cAMP-specific PDE
Systematic name:
3',5'-cyclic-AMP 5'-nucleotidohydrolase




Requires Mg2+ or Mn2+ for activity [2]. This enzyme is specific for 3',5'-cAMP and does not hydrolyse other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC, 3',5'-cyclic-nucleotide phosphodiesterase and EC, 3',5'-cyclic-GMP phosphodiesterase). It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00116
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004115
UniProtKB/Swiss-Prot: (119) [show] [UniProt]


  1. Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiä, M.M.
    TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi.
    Mol. Biochem. Parasitol. 145 : 40-49 (2006). [PMID: 16225937]
  2. Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J.M.
    DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells.
    J. Biol. Chem. 281 : 20018-20026 (2006). [PMID: 16644729]
  3. Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A.
    Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei.
    Proc. Natl. Acad. Sci. USA 99 : 4714-4719 (2002). [PMID: 11930017]
  4. Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T.
    Cyclic nucleotide specific phosphodiesterases of Leishmania major.
    BMC Microbiol. 6 : 25 (2006). [PMID: 16522215]
  5. Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E.
    Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei.
    Biochim. Biophys. Acta 1472 : 431-446 (1999). [PMID: 10564757]
  6. Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A., Niki, H.
    Identification of the cpdA gene encoding cyclic 3',5'-adenosine monophosphate phosphodiesterase in Escherichia coli.
    J. Biol. Chem. 271 : 25423-25429 (1996). [PMID: 8810311]

[EC created 2008, modifed 2011]