IntEnz

EC 3.1.4.4 - Phospholipase D

IntEnz Enzyme Nomenclature
EC 3.1.4.4

Names

Reactions

• 14445 [IUBMB]
  a 1,2-diacyl-sn-glycero-3-phosphocholine

  a 1,2-diacyl-sn-glycero-3-phosphocholine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57643

  Formula: C10H18NO8PR2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  a 1,2-diacyl-sn-glycero-3-phosphate

  a 1,2-diacyl-sn-glycero-3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:58608

  Formula: C5H5O8PR2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  choline

  choline

  Name origin: UniProt - CHECKED (C)

  CHEBI:15354

  Formula: C5H14NO
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 38995
  a 1-acyl-sn-glycero-3-phosphocholine

  a 1-acyl-sn-glycero-3-phosphocholine

  Name origin: UniProt - CHECKED (C)

  CHEBI:58168

  Formula: C9H19NO7PR
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  a 1-acyl-sn-glycero-3-phosphate

  a 1-acyl-sn-glycero-3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:57970

  Formula: C4H6O7PR
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  choline

  choline

  Name origin: UniProt - CHECKED (C)

  CHEBI:15354

  Formula: C5H14NO
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 36219
  1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

  1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

  Name origin: UniProt - CHECKED (C)

  CHEBI:77290

  Formula: C8H14NO7PR2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate

  1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:77284

  Formula: C6H7O7PR2
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  ethanolamine

  ethanolamine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57603

  Formula: C2H8NO
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

Also acts on other phosphatidyl esters.

Links to other databases

References

1. Astrachan, L.
   The bond hydrolyzed by cardiolipin-specific phospholipase D.
   Biochim. Biophys. Acta 296: 79-88 (1973). [PMID: 4632675]
2. Einset, E. and Clark, W.L.
   The enzymatically catalyzed release of choline from lecithin.
   J. Biol. Chem. 231: 703-715 (1958).
3. Hanahan, D.J. and Chaikoff, I.L.
   On the nature of the phosphorus-containing lipides of cabbage leaves and their relation to a phospholipide-splitting enzyme contained in these leaves.
   J. Biol. Chem. 172: 191-198 (1948).
4. Tookey, H.L. and Balls, A.K.
   Plant phospholipase D. I. Studies on cottonseed and cabbage phospholipase D.
   J. Biol. Chem. 218: 213-224 (1956).

[EC 3.1.4.4 created 1961]