EC - Phospholipase D

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IntEnz Enzyme Nomenclature


Accepted name:
phospholipase D
Other names:
choline phosphatase
lecithinase D
lipophosphodiesterase II
Systematic name:
phosphatidylcholine phosphatidohydrolase



Also acts on other phosphatidyl esters.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0070290 , GO:0004630
CAS Registry Number: 9001-87-0
UniProtKB/Swiss-Prot: (58) [show] [UniProt]


  1. Astrachan, L.
    The bond hydrolyzed by cardiolipin-specific phospholipase D.
    Biochim. Biophys. Acta 296 : 79-88 (1973). [PMID: 4632675]
  2. Einset, E. and Clark, W.L.
    The enzymatically catalyzed release of choline from lecithin.
    J. Biol. Chem. 231 : 703-715 (1958).
  3. Hanahan, D.J. and Chaikoff, I.L.
    On the nature of the phosphorus-containing lipides of cabbage leaves and their relation to a phospholipide-splitting enzyme contained in these leaves.
    J. Biol. Chem. 172 : 191-198 (1948).
  4. Tookey, H.L. and Balls, A.K.
    Plant phospholipase D. I. Studies on cottonseed and cabbage phospholipase D.
    J. Biol. Chem. 218 : 213-224 (1956).

[EC created 1961]