EC - 2',3'-cyclic-nucleotide 3'-phosphodiesterase

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IntEnz Enzyme Nomenclature


Accepted name:
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Other names:
2',3'-cyclic AMP phosphodiesterase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotide 3'-phosphohydrolase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide 3'-phosphodiesterase
cyclic 2',3'-nucleotide 3'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
cyclic-CMP phosphodiesterase
Systematic name:
nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase



The brain enzyme acts on 2',3'-cyclic AMP more rapidly than on the UMP or CMP derivatives. An enzyme from liver acts on 2',3'-cyclic CMP more rapidly than on the purine derivatives; it also hydrolyses the corresponding 3',5'-cyclic phosphates, but more slowly. This latter enzyme has been called cyclic-CMP phosphodiesterase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004113
CAS Registry Number: 60098-35-3
UniProtKB/Swiss-Prot: (16) [show] [UniProt]


  1. Drummond, G.I., Iyer, N.T. and Keith, J.
    Hydrolysis of ribonucleoside 2',3'-cyclic phosphates by a diesterase from brain.
    J. Biol. Chem. 237 : 3535-3539 (1962).
  2. Helfman, D.M. and Kuo, J.F.
    A homogeneous cyclic CMP phosphodiesterase hydrolyzes both pyrimidine and purine cyclic 2':3'- and 3':5'-nucleotides.
    J. Biol. Chem. 257 : 1044-1047 (1982). [PMID: 6274851]
  3. Helfman, D.M., Shoji, M. and Kuo, J.F.
    Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
    J. Biol. Chem. 256 : 6327-6334 (1981). [PMID: 6263914]
  4. Kurihara, T., Nishizawa, Y., Takahashi, Y. and Odani, S.
    Chemical, immunological and catalytic properties of 2':3'-cyclic nucleotide 3'-phosphodiesterase purified from brain white matter.
    Biochem. J. 195 : 153-157 (1981). [PMID: 6272743]
  5. Nishizawa, Y., Kurihara, T. and Takahashi, Y.
    Spectrophotometric assay, solubilization and purification of brain 2':3'-cyclic nucleotide 3'-phosphodiesterase.
    Biochem. J. 191 : 71-82 (1980). [PMID: 6258586]

[EC created 1976]