EC - 3',5'-cyclic-nucleotide phosphodiesterase

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IntEnz Enzyme Nomenclature


Accepted name:
3',5'-cyclic-nucleotide phosphodiesterase
Other names:
3', 5'-cyclic nucleoside monophosphate phosphodiesterase
3',5'-cyclonucleotide phosphodiesterase
3',5'-nucleotide phosphodiesterase
3': 5'-monophosphate phosphodiesterase (cyclic CMP)
3':5'-cyclic nucleotide 5'-nucleotidohydrolase
cyclic 3',5'-mononucleotide phosphodiesterase
cyclic 3',5'-nucleotide phosphodiesterase
cyclic 3',5'-phosphodiesterase
cyclic 3',5-nucleotide monophosphate phosphodiesterase
cyclic nucleotide phosphodiesterase
cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP)
nucleoside 3',5'-cyclic phosphate diesterase
nucleoside-3',5-monophosphate phosphodiesterase
cyclic AMP phosphodiesterase
Systematic name:
3',5'-cyclic-nucleotide 5'-nucleotidohydrolase



Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00116 , PROSITE:PDOC00530
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004114
CAS Registry Number: 9040-59-9
UniProtKB/Swiss-Prot: (79) [show] [UniProt]


  1. Fischer, U. and Amrhein, N.
    Cyclic nucleotide phosphodiesterase of Chlamydomonas reinhardtii.
    Biochim. Biophys. Acta 341 : 412-420 (1974). [PMID: 4365506]
  2. Nair, K.G.
    Purification and properties of 3',5'-cyclic nucleotide phosphodiesterase from dog heart.
    Biochemistry 5 : 150-157 (1966). [PMID: 4287216]

[EC created 1972, modified 1976]