EC 3.1.4.16 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase
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ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.4.16
Names
Accepted name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase
Other
names:
2',3 '-cyclic AMP phosphodiesterase
2',3'-cyclic AMP 2'-phosphohydrolase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotidase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase
2':3'-cyclic phosphodiesterase
cyclic 2',3'-nucleotide 2'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
cyclic phosphodiesterase:3'-nucleotidase
ribonucleoside 2',3'-cyclic phosphate diesterase
2',3'-cyclic AMP 2'-phosphohydrolase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotidase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase
2':3'-cyclic phosphodiesterase
cyclic 2',3'-nucleotide 2'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
cyclic phosphodiesterase:3'-nucleotidase
ribonucleoside 2',3'-cyclic phosphate diesterase
Systematic name:
nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase
Reactions
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19621 [IUBMB]a nucleoside 2',3'-cyclic phosphateName origin: UniProt - CHECKED (C)Formula: C5H7O6PR
Charge: -1ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=a nucleoside 3'-phosphateName origin: UniProt - CHECKED (C)Formula: C5H8O7PR
Charge: -2ChEBI compound status: CHECKED (C) -
2',3'-cyclic GMPName origin: UniProt - CHECKED (C)Formula: C10H11N5O7P
Charge: -1ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=3'-GMPName origin: UniProt - CHECKED (C)Formula: C10H12N5O8P
Charge: -2ChEBI compound status: CHECKED (C) -
2',3'-cyclic UMPName origin: UniProt - CHECKED (C)Formula: C9H10N2O8P
Charge: -1ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=3'-UMPName origin: UniProt - CHECKED (C)Formula: C9H11N2O9P
Charge: -2ChEBI compound status: CHECKED (C) -
2',3'-cyclic CMPName origin: UniProt - CHECKED (C)Formula: C9H11N3O7P
Charge: -1ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=3'-CMPName origin: UniProt - CHECKED (C)Formula: C9H12N3O8P
Charge: -2ChEBI compound status: CHECKED (C) -
2',3'-cyclic AMPName origin: UniProt - CHECKED (C)Formula: C10H11N5O6P
Charge: -1ChEBI compound status: CHECKED (C)H2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=3'-AMPName origin: UniProt - CHECKED (C)Formula: C10H12N5O7P
Charge: -2ChEBI compound status: CHECKED (C)
Comments:
Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease).
Links to other databases
Protein domains and families:
PROSITE:PDOC00627
Gene Ontology:
GO:0008663
CAS Registry Number:
9037-18-7
UniProtKB/Swiss-Prot:
CPDB_ECOLI
CPDB_HAEIN
CPDB_SALTY
CPDB_YEREN
NTPES_BACSU
PPDE_DEIRA
YMDB_BACSU
References
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A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. I. Purification and some properties of the enzyme.J. Biol. Chem. 239 : 3412-3419 (1964).
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A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme.J. Biol. Chem. 239 : 3420-3424 (1964).
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A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis.J. Biol. Chem. 243 : 138-143 (1968). [PMID: 4295113]
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Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain.Can. J. Biochem. 47 : 961-966 (1969). [PMID: 4310670]
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Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus.Biochim. Biophys. Acta 171 : 89-102 (1969). [PMID: 4303200]
[EC 3.1.4.16 created 1972, modified 1976]