IntEnz

EC 3.1.4.16 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase

IntEnz Enzyme Nomenclature
EC 3.1.4.16

Names

Reactions

• 19621 [IUBMB]
  a nucleoside 2',3'-cyclic phosphate

  a nucleoside 2',3'-cyclic phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:66954

  Formula: C5H7O6PR
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  a nucleoside 3'-phosphate

  a nucleoside 3'-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:66949

  Formula: C5H8O7PR
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 27858
  2',3'-cyclic GMP

  2',3'-cyclic GMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60837

  Formula: C10H11N5O7P
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3'-GMP

  3'-GMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60732

  Formula: C10H12N5O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 27878
  2',3'-cyclic UMP

  2',3'-cyclic UMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60873

  Formula: C9H10N2O8P
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3'-UMP

  3'-UMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60784

  Formula: C9H11N2O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 27882
  2',3'-cyclic CMP

  2',3'-cyclic CMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60877

  Formula: C9H11N3O7P
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3'-CMP

  3'-CMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60875

  Formula: C9H12N3O8P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  
• 27886
  2',3'-cyclic AMP

  2',3'-cyclic AMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60879

  Formula: C10H11N5O6P
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  3'-AMP

  3'-AMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:60880

  Formula: C10H12N5O7P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 4.6.1.24 (ribonuclease T1) and EC 4.6.1.18 (pancreatic ribonuclease).

Links to other databases

References

1. Anraku, Y.
   A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. I. Purification and some properties of the enzyme.
   J. Biol. Chem. 239 : 3412-3419 (1964).
2. Anraku, Y.
   A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme.
   J. Biol. Chem. 239 : 3420-3424 (1964).
3. Center, M.S. and Behal, F.J.
   A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis.
   J. Biol. Chem. 243 : 138-143 (1968). [PMID: 4295113]
4. Olafson, R.W., Drummond, G.I. and Lee, J.F.
   Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain.
   Can. J. Biochem. 47 : 961-966 (1969). [PMID: 4310670]
5. Unemoto, T. and Hayashi, M.
   Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus.
   Biochim. Biophys. Acta 171 : 89-102 (1969). [PMID: 4303200]

[EC 3.1.4.16 created 1972, modified 1976]