EC 188.8.131.52 - 2',3'-cyclic-nucleotide 2'-phosphodiesterase
IntEnz Enzyme Nomenclature
2',3'-cyclic AMP 2'-phosphohydrolase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase
cyclic 2',3'-nucleotide 2'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
ribonucleoside 2',3'-cyclic phosphate diesterase
- nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate
Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC 184.108.40.206 (ribonuclease T1) and EC 220.127.116.11 (pancreatic ribonuclease).
Links to other databases
A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. I. Purification and some properties of the enzyme.J. Biol. Chem. 239 : 3412-3419 (1964).
A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme.J. Biol. Chem. 239 : 3420-3424 (1964).
A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis.J. Biol. Chem. 243 : 138-143 (1968). [PMID: 4295113]
Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain.Can. J. Biochem. 47 : 961-966 (1969). [PMID: 4310670]
Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus.Biochim. Biophys. Acta 171 : 89-102 (1969). [PMID: 4303200]
[EC 18.104.22.168 created 1972, modified 1976]