EC - 2',3'-cyclic-nucleotide 2'-phosphodiesterase

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IntEnz Enzyme Nomenclature


Accepted name:
2',3'-cyclic-nucleotide 2'-phosphodiesterase
Other names:
2',3 '-cyclic AMP phosphodiesterase
2',3'-cyclic AMP 2'-phosphohydrolase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotidase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase
2':3'-cyclic phosphodiesterase
cyclic 2',3'-nucleotide 2'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
cyclic phosphodiesterase:3'-nucleotidase
ribonucleoside 2',3'-cyclic phosphate diesterase
Systematic name:
nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase



Also hydrolyses 3'-nucleoside monophosphates and bis-4-nitrophenyl phosphate, but not 3'-deoxynucleotides. Similar reactions are carried out by EC (ribonuclease T1) and EC (pancreatic ribonuclease).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00627
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008663
CAS Registry Number: 9037-18-7


  1. Anraku, Y.
    A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. I. Purification and some properties of the enzyme.
    J. Biol. Chem. 239 : 3412-3419 (1964).
  2. Anraku, Y.
    A new cyclic phosphodiesterase having a 3'-nucleotidase activity from Escherichia coli B. II. Further studies on substrate specificity and mode of action of the enzyme.
    J. Biol. Chem. 239 : 3420-3424 (1964).
  3. Center, M.S. and Behal, F.J.
    A cyclic phosphodiesterase with 3'-nucleotidase activity from Proteus mirabilis.
    J. Biol. Chem. 243 : 138-143 (1968). [PMID: 4295113]
  4. Olafson, R.W., Drummond, G.I. and Lee, J.F.
    Studies on 2',3'-cyclic nucleotide-3'-phosphohydrolase from brain.
    Can. J. Biochem. 47 : 961-966 (1969). [PMID: 4310670]
  5. Unemoto, T. and Hayashi, M.
    Chloride ion as a modifier of 2',3'-cyclic phosphodiesterase purified from halophilic Vibrio alginolyticus.
    Biochim. Biophys. Acta 171 : 89-102 (1969). [PMID: 4303200]

[EC created 1972, modified 1976]