EC 3.1.4.11 - Phosphoinositide phospholipase C
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.4.11
Names
Accepted name:
phosphoinositide phospholipase C
Other
names:
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
triphosphoinositide phosphodiesterase
PI-PLC
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
triphosphoinositide phosphodiesterase
PI-PLC
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
Reaction
- 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Comments:
These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found.
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0004435
CAS Registry Number:
37213-51-7
References
-
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.Biochem. J. 198 : 133-140 (1981). [PMID: 6275838]
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The triphosphoinositide phosphodiesterase of brain tissue.Biochem. J. 91 : 237-243 (1964). [PMID: 4284484]
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Regulation of phosphoinositide-specific phospholipase C isozymes.J. Biol. Chem. 272 : 15045-15048 (1997). [PMID: 9182519]
[EC 3.1.4.11 created 1972, modified 2002]