EC - Phosphoinositide phospholipase C

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoinositide phospholipase C
Other names:
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
monophosphatidylinositol phosphodiesterase
phosphatidylinositol phospholipase C
phosphoinositidase C
triphosphoinositide phosphodiesterase
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase



These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004435
CAS Registry Number: 37213-51-7
UniProtKB/Swiss-Prot: (133) [show] [UniProt]


  1. Downes, C.P. and Michell, R.H.
    The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
    Biochem. J. 198 : 133-140 (1981). [PMID: 6275838]
  2. Thompson, W. and Dawson, R.M.C.
    The triphosphoinositide phosphodiesterase of brain tissue.
    Biochem. J. 91 : 237-243 (1964). [PMID: 4284484]
  3. Rhee, S.G. and Bae, Y.S.
    Regulation of phosphoinositide-specific phospholipase C isozymes.
    J. Biol. Chem. 272 : 15045-15048 (1997). [PMID: 9182519]

[EC created 1972, modified 2002]