EC - Micrococcal nuclease

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IntEnz Enzyme Nomenclature


Accepted name:
micrococcal nuclease
Other names:
Staphylococcus aureus nuclease
Staphylococcus aureus nuclease B
micrococcal endonuclease
nuclease T
nuclease T'
ribonucleate (deoxynucleate) 3'-nucleotidohydrolase
spleen endonuclease
spleen phosphodiesterase
staphylococcal nuclease
Systematic name:



Hydrolyses double- or single-stranded substrate. Formerly EC cf. EC spleen exonuclease.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00865
Structural data: CSA , EC2PDB
CAS Registry Number: 9013-53-0
UniProtKB/Swiss-Prot: (16) [show] [UniProt]


  1. Alexander, M., Heppel, L.A. and Hurwitz, J.
    The purification and properties of micrococcal nuclease.
    J. Biol. Chem. 236 : 3014-3019 (1961).
  2. Anfinsen, C.B., Cuatrecasas, P. and Taniuchi, H.
    Staphylococcal nuclease, chemical properties and catalysis.
    In: Boyer, P.D. (Ed.) The Enzymes , 3rd ed. vol. 4 , Academic Press , New York , 1971 , 177-204
  3. Reddi, K.K.
    Micrococcal nuclease.
    Methods Enzymol. 12A : 257-262 (1967).
  4. Sulkowski, E. and Laskowski, M., Sr.
    Phosphatase-free crystalline micrococcal nuclease.
    J. Biol. Chem. 241 : 4386-4388 (1966). [PMID: 5922962]

[EC created 1961 as EC, transferred 1978 to EC, modified 1981]