EC - IMP-specific 5'-nucleotidase

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IntEnz Enzyme Nomenclature


Accepted name:
IMP-specific 5'-nucleotidase
Other name:
ISN1 (gene name)
Systematic name:
inosine 5'-phosphate phosphohydrolase




The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (21) [show] [UniProt]


  1. Itoh, R.
    Purification and some properties of an IMP-specific 5'-nucleotidase from yeast.
    Biochem. J. 298 Pt 3 : 593-598 (1994). [PMID: 8141771]
  2. Itoh, R., Saint-Marc, C., Chaignepain, S., Katahira, R., Schmitter, J. M., Daignan-Fornier, B.
    The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.
    BMC Biochem. 4 : 4 (2003). [PMID: 12735798]

[EC created 2016]