EC - Glucose-6-phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
Other name:
glucose 6-phosphate phosphatase
Systematic name:
D-glucose-6-phosphate phosphohydrolase



Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC (phosphoramidate-hexose phosphotransferase), EC (diphosphate-glycerol phosphotransferase) and EC (phosphoamidase)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004346
CAS Registry Number: 9001-39-2
UniProtKB/Swiss-Prot: (19) [show] [UniProt]


  1. Anchors, J.M. and Karnovsky, N.L.
    Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep.
    J. Biol. Chem. 250 : 6408-6416 (1975). [PMID: 169241]
  2. Colilla, W., Jorgenson, R.A. and Nordlie, R.C.
    Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution.
    Biochim. Biophys. Acta 377 : 117 (1975). [PMID: 164220]
  3. Nordlie, R.C.
    Glucose-6-phosphatase, hydrolytic and synthetic activities.
    In: Boyer, P.D. (Ed.) The Enzymes , 3rd ed. vol. 4 , Academic Press , New York , 1971 , 543-610
  4. Nordlie, R.C.
    Metabolic regulation by multifunctional glucose-6-phosphatase.
    Curr. Top. Cell. Regul. 8 : 33 (1974). [PMID: 4370737]

[EC created 1961]