IntEnz

EC 3.1.3.86 - Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

IntEnz Enzyme Nomenclature
EC 3.1.3.86

Names

Reaction

• 25528 [IUBMB]
  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

  a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57836

  Formula: C11H13O22P4R2
  Charge: -7

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)

  1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)

  Name origin: UniProt - CHECKED (C)

  CHEBI:57658

  Formula: C11H14O19P3R2
  Charge: -5

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

This enzyme hydrolyses phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P₃) to produce PtdIns(3,4)P₂, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward PtdIns(1,3,4,5)P₄ [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.

Links to other databases

References

1. Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A., Rohrschneider, L. R.
   p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
   Genes Dev. 10: 1084-1095 (1996). [PMID: 8654924]
2. Damen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., Krystal, G.
   The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
   Proc. Natl. Acad. Sci. USA 93: 1689-1693 (1996). [PMID: 8643691]
3. Giuriato, S., Payrastre, B., Drayer, A. L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C., Chap, H.
   Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
   J. Biol. Chem. 272: 26857-26863 (1997). [PMID: 9341117]
4. Drayer, A. L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P., Erneux, C.
   Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
   Biochem. Biophys. Res. Commun. 225: 243-249 (1996). [PMID: 8769125]
5. Pesesse, X., Moreau, C., Drayer, A. L., Woscholski, R., Parker, P., Erneux, C.
   The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.
   FEBS Lett. 437: 301-303 (1998). [PMID: 9824312]

[EC 3.1.3.86 created 2011]