EC 3.1.3.86 - Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.3.86
Names
Accepted name:
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
Other
names:
SHIP1
SHIP
p150Ship
SHIP2
SHIP
p150Ship
SHIP2
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase
Reaction
- 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Comments:
This enzyme hydrolyses phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward PtdIns(1,3,4,5)P4 [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects.
Links to other databases
References
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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.Genes Dev. 10 : 1084-1095 (1996). [PMID: 8654924]
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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.Proc. Natl. Acad. Sci. USA 93 : 1689-1693 (1996). [PMID: 8643691]
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Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.J. Biol. Chem. 272 : 26857-26863 (1997). [PMID: 9341117]
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Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.Biochem. Biophys. Res. Commun. 225 : 243-249 (1996). [PMID: 8769125]
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The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity.FEBS Lett. 437 : 301-303 (1998). [PMID: 9824312]
[EC 3.1.3.86 created 2011]