IntEnz

EC 3.1.3.83 - D-glycero-α-D-manno-heptose-1,7-bisphosphate 7-phosphatase

IntEnz Enzyme Nomenclature
EC 3.1.3.83

Names

Reaction

• 28522 [IUBMB]
  D-glycero-α-D-manno-heptose 1,7-bisphosphate

  D-glycero-alpha-D-manno-heptose 1,7-bisphosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:60207

  Formula: C7H12O13P2
  Charge: -4

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  D-glycero-α-D-manno-heptose 1-phosphate

  D-glycero-alpha-D-manno-heptose 1-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:61574

  Formula: C7H13O10P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  phosphate

  phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:43474

  Formula: HO4P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the α-anomer than with the β-anomer [1].

Links to other databases

References

1. Wang, L., Huang, H., Nguyen, H. H., Allen, K. N., Mariano, P. S., Dunaway-Mariano, D.
   Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
   Biochemistry 49 : 1072-1081 (2010). [PMID: 20050615]

[EC 3.1.3.83 created 2010]