EC 3.1.3.83 - D-glycero-α-D-manno-heptose-1,7-bisphosphate 7-phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.83

Names

Accepted name:
D-glycero-α-D-manno-heptose-1,7-bisphosphate 7-phosphatase
Other name:
gmhB
Systematic name:
D-glycero-α-D-manno-heptose-1,7-bisphosphate 7-phosphohydrolase

Reaction

Comments:

The enzyme is involved in biosynthesis of GDP-D-glycero-α-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria. The in vitro catalytic efficiency of the enzyme from Bacteroides thetaiotaomicron is 6-fold higher with the α-anomer than with the β-anomer [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Wang, L., Huang, H., Nguyen, H. H., Allen, K. N., Mariano, P. S., Dunaway-Mariano, D.
    Divergence of biochemical function in the HAD superfamily: D-glycero-D-manno-heptose-1,7-bisphosphate phosphatase (GmhB).
    Biochemistry 49 : 1072-1081 (2010). [PMID: 20050615]

[EC 3.1.3.83 created 2010]