EC 3.1.3.78 - Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.1.3.78

Names

Accepted name:
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Other names:
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II
type I PtdIns-4,5-P2 4-Ptase
type II PtdIns-4,5-P2 4-Ptase
IpgD
PtdIns-4,5-P2 4-phosphatase type I
PtdIns-4,5-P24-phosphatase type II
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase
type 1 4-phosphatase
PtdIns-4,5-P2 4-phosphatase
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase

Reaction

Comments:

Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B.
    Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
    EMBO J. 21: 5069-5078 (2002). [PMID: 12356723]
  2. Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.-C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W.
    The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
    Proc. Natl. Acad. Sci. USA 102: 18854-18859 (2005). [PMID: 16365287]
  3. Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W.
    Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
    Proc. Natl. Acad. Sci. USA 104: 16834-16839 (2007). [PMID: 17940011]
  4. Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S.
    Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
    J. Gen. Physiol. 129: 267-283 (2007). [PMID: 17389247]

[EC 3.1.3.78 created 2008]