EC - Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Other names:
phosphatidylinositol-4,5-bisphosphate 4-phosphatase I
phosphatidylinositol-4,5-bisphosphate 4-phosphatase II
type I PtdIns-4,5-P2 4-Ptase
type II PtdIns-4,5-P2 4-Ptase
PtdIns-4,5-P2 4-phosphatase type I
PtdIns-4,5-P24-phosphatase type II
type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase
type 1 4-phosphatase
PtdIns-4,5-P2 4-phosphatase
Systematic name:
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase



Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot: (15) [show] [UniProt]


  1. Niebuhr, K., Giuriato, S., Pedron, T., Philpott, D.J., Gaits, F., Sable, J., Sheetz, M.P., Parsot, C., Sansonetti, P.J. and Payrastre, B.
    Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.
    EMBO J. 21: 5069-5078 (2002). [PMID: 12356723]
  2. Ungewickell, A., Hugge, C., Kisseleva, M., Chang, S.-C., Zou, J., Feng, Y., Galyov, E.E., Wilson, M. and Majerus, P.W.
    The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases.
    Proc. Natl. Acad. Sci. USA 102: 18854-18859 (2005). [PMID: 16365287]
  3. Zou, J., Marjanovic, J., Kisseleva, M.V., Wilson, M. and Majerus, P.W.
    Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis.
    Proc. Natl. Acad. Sci. USA 104: 16834-16839 (2007). [PMID: 17940011]
  4. Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L. and Grinstein, S.
    Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
    J. Gen. Physiol. 129: 267-283 (2007). [PMID: 17389247]

[EC created 2008]