EC 3.1.3.75 - Phosphoethanolamine/phosphocholine phosphatase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.1.3.75

Names

Accepted name:
phosphoethanolamine/phosphocholine phosphatase
Other names:
3X11A
PHOSPHO1
Systematic name:
phosphoethanolamine phosphohydrolase

Reactions

Cofactor

Comments:

Requires active site Mg2+ but also works, to a lesser extent, with Co2+ and Mn2+. The enzyme is highly specific for phosphoethanolamine and phosphocholine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052731 , GO:0052732
UniProtKB/Swiss-Prot:

References

  1. Houston, B., Seawright, E., Jefferies, D., Hoogland, E., Lester, D., Whitehead, C. and Farquharson, C.
    Identification and cloning of a novel phosphatase expressed at high levels in differentiating growth plate chondrocytes.
    Biochim. Biophys. Acta 1448: 500-506 (1999). [PMID: 9990301]
  2. Stewart, A.J., Schmid, R., Blindauer, C.A., Paisey, S.J. and Farquharson, C.
    Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily.
    Protein Eng. 16: 889-895 (2004). [PMID: 14983068]
  3. Roberts, S.J., Stewart, A.J., Sadler, P.J. and Farquharson, C.
    Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities.
    Biochem. J. 382: 59-65 (2003). [PMID: 15175005]

[EC 3.1.3.75 created 2004]