EC 3.1.3.73 - Adenosylcobalamin/α-ribazole phosphatase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.3.73
Names
Accepted name:
adenosylcobalamin/α-ribazole phosphatase
Other
names:
CobC
adenosylcobalamin phosphatase
α-ribazole phosphatase
adenosylcobalamin phosphatase
α-ribazole phosphatase
Systematic name:
adenosylcobalamin/α-ribazole-5'-phosphate phosphohydrolase
Reactions
- (1) adenosylcobalamin 5'-phosphate + H2O = coenzyme B12 + phosphate
- (2) alpha-ribazole 5'-phosphate + H2O = alpha-ribazole + phosphate
Comments:
This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Gene Ontology:
GO:0043755
CAS Registry Number:
251991-06-7
UniProtKB/Swiss-Prot:
References
-
The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.J. Biol. Chem. 269 : 26503-26511 (1994). [PMID: 7929373]
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The biosynthesis of adenosylcobalamin (vitamin B12).Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]
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Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway.J. Bacteriol. 189 : 2210-2218 (2007). [PMID: 17209023]
[EC 3.1.3.73 created 2004, modified 2011]