EC - Adenosylcobalamin/α-ribazole phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
adenosylcobalamin/α-ribazole phosphatase
Other names:
adenosylcobalamin phosphatase
α-ribazole phosphatase
Systematic name:
adenosylcobalamin/α-ribazole-5'-phosphate phosphohydrolase



This enzyme catalyses the last step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis, characterized in Salmonella enterica [3]. It also participates in a salvage pathway that recycles cobinamide into adenosylcobalamin [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0043755
CAS Registry Number: 251991-06-7


  1. O'Toole, G.A., Trzebiatowski, J.R. and Escalante-Semerena, J.C.
    The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.
    J. Biol. Chem. 269 : 26503-26511 (1994). [PMID: 7929373]
  2. Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C.
    The biosynthesis of adenosylcobalamin (vitamin B12).
    Nat. Prod. Rep. 19 : 390-412 (2002). [PMID: 12195810]
  3. Zayas, C. L., Escalante-Semerena, J. C.
    Reassessment of the late steps of coenzyme B12 synthesis in Salmonella enterica: evidence that dephosphorylation of adenosylcobalamin-5'-phosphate by the CobC phosphatase is the last step of the pathway.
    J. Bacteriol. 189 : 2210-2218 (2007). [PMID: 17209023]

[EC created 2004, modified 2011]