EC - Multiple inositol-polyphosphate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
multiple inositol-polyphosphate phosphatase
Other names:
inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase
inositol 1,3,4,5-tetrakisphosphate 3-phosphomonoesterase
inositol 1,3,4,5-tetrakisphosphate-5-phosphomonoesterase
inositol tetrakisphosphate phosphomonoesterase
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase
Systematic name:
1D-myo-inositol-hexakisphosphate 5-phosphohydrolase



This enzyme exists in two isoforms. It also acts on Ins(1,3,4,5)P4 to yield Ins(1,4,5)P3.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052826 , GO:0004446
CAS Registry Number: 116958-30-6


  1. Cullen, P.J., Irvine, R.F., Drøbak, B.J. and Dawson, A.P.
    Inositol 1,3,4,5-tetrakisphosphate causes release of Ca2+ from permeabilized mouse lymphoma L1210 cells by its conversion into inositol 1,4,5-trisphosphate.
    Biochem. J. 259: 931-933 (1989). [PMID: 2786415]
  2. Craxton, A., Caffrey, J.J., Burkhart, W., Safrany, S.T. and Shears, S.B.
    Molecular cloning and expression of a rat hepatic multiple inositol polyphosphate phosphatase.
    Biochem. J. 328: 75-81 (1997). [PMID: 9359836]

[EC created 1992, modified 2002]