EC - Inositol-1,4-bisphosphate 1-phosphatase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
inositol-1,4-bisphosphate 1-phosphatase
Other names:
inositol-polyphosphate 1-phosphatase
inositol polyphosphate 1-phosphatase
Systematic name:
1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase



The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00547
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004441
CAS Registry Number: 111070-17-8


  1. Berridge, M.J., Dawson, R.M.C., Downes, C.P., Heslop, J.P. and Irvine, R.F.
    Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides.
    Biochem. J. 212: 473-482 (1983). [PMID: 6309146]
  2. Connolly, T.M., Bansal, V.S., Bross, T.E., Irvine, R.F. and Majerus, P.W.
    The metabolism of tris- and tetraphosphates of inositol by 5-phosphomonoesterase and 3-kinase enzymes.
    J. Biol. Chem. 262: 2146-2149 (1987). [PMID: 3029066]
  3. Inhorn, R.C. and Majerus, P.W.
    Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+.
    J. Biol. Chem. 262: 15946-15952 (1987). [PMID: 2824473]

[EC created 1989, modified 2002]