EC - Inositol-polyphosphate 5-phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
inositol-polyphosphate 5-phosphatase
Other names:
myo-inositol-1,4,5-trisphosphate 5-phosphatase
D-myo-inositol 1,4,5-triphosphate 5-phosphatase
D-myo-inositol 1,4,5-trisphosphate 5-phosphatase
D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase
L-myo-inositol 1,4,5-trisphosphate-monoesterase
Ins(1,4,5)P3 5-phosphatase
Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase
InsP3/Ins(1,3,4,5)P4 5-phosphatase
inosine triphosphatase
inositol 1,4,5-trisphosphate phosphatase
inositol phosphate 5-phosphomonoesterase
inositol polyphosphate-5-phosphatase
inositol trisphosphate phosphomonoesterase
inositol-1,4,5-trisphosphate 5-phosphatase
inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase
type I inositol-polyphosphate phosphatase
Systematic name:
1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase



One mammalian isoform is known. This enzyme is distinguished from the family of enzymes classified under EC, phosphoinositide 5-phosphatase, by its inability to dephosphorylate inositol lipids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052659 , GO:0052658 , GO:0004445
CAS Registry Numbers: 106283-14-1 9082-57-9
UniProtKB/Swiss-Prot: (38) [show] [UniProt]


  1. Downes, C.P., Mussat, M.C. and Michell, R.H.
    The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane.
    Biochem. J. 203 : 169-177 (1982). [PMID: 6285891]
  2. Erneux, C., Lemos, M., Verjans, B., Vanderhaeghen, P., Delvaux, A. and Dumont, J.E.
    Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain.
    Eur. J. Biochem. 181 : 317-322 (1989). [PMID: 2540972]
  3. Woscholski, R. and Parker, P.J.
    Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
    In: Cockcroft, S. (Ed.) Biology of Phosphoinositides , Oxford University Press , Oxford , 2000 , 320-338
  4. Verjans, B., De Smedt, F., Lecocq, R., Vanweyenberg, V., Moreau, C. and Erneux, C.
    Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase.
    Biochem. J. 300 : 85-90 (1994). [PMID: 8198557]

[EC created 1989, modified 2002]