EC 3.1.3.4 - Phosphatidate phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.4

Names

Accepted name:
phosphatidate phosphatase
Other names:
acid phosphatidyl phosphatase
phosphatic acid phosphatase
phosphatic acid phosphohydrolase
phosphatidic acid phosphatase
PAP
lipin
Systematic name:
diacylglycerol-3-phosphate phosphohydrolase

Reaction

Cofactor

Comments:

This enzyme catalyses the Mg2+-dependent dephosphorylation of a 1,2-diacylglycerol-3-phosphate, yielding a 1,2-diacyl-sn-glycerol (DAG), the substrate for de novo lipid synthesis via the Kennedy pathway and for the synthesis of triacylglycerol. In lipid signaling, the enzyme generates a pool of DAG to be used for protein kinase C activation. The mammalian enzymes are known as lipins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008195
CAS Registry Number: 9025-77-8
UniProtKB/Swiss-Prot: (61) [show] [UniProt]

References

  1. Smith, S.W., Weiss, S.B. and Kennedy, E.P.
    The enzymatic dephosphorylation of phosphatidic acids.
    J. Biol. Chem. 228 : 915-922 (1957). [PMID: 3475370]
  2. Carman, G.M., Han, G.S.
    Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
    J. Biol. Chem. 284 : 2593-2597 (2009). [PMID: 18812320]

[EC 3.1.3.4 created 1961, modified 2010]