EC - Phosphoinositide 5-phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoinositide 5-phosphatase
Other names:
IP3 phosphatase
PtdIns(4,5)P2 phosphatase
diphosphoinositide phosphatase
inositol 1,4,5-triphosphate 5-phosphomonoesterase
inositol triphosphate 5-phosphomonoesterase
phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase
phosphatidyl-inositol-bisphosphate phosphatase
phosphatidylinositol 4,5-bisphosphate phosphatase
polyphosphoinositol lipid 5-phosphatase
triphosphoinositide phosphatase
triphosphoinositide phosphomonoesterase
type II inositol polyphosphate 5-phosphatase
type II inositol-1,4,5-trisphosphate 5-phosphatase
Systematic name:
phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase



These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC, inositol-polyphosphate 5-phosphatase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004439
CAS Registry Number: 9036-01-5
UniProtKB/Swiss-Prot: (76) [show] [UniProt]


  1. Dawson, R.M.C. and Thompson, W.
    The triphosphoinositide phosphomonoesterase of brain tissue.
    Biochem. J. 91 : 244-250 (1964). [PMID: 4284485]
  2. Roach, P.D. and Palmer, F.B.S.
    Human erythrocyte cytosol phosphatidyl-inositol-bisphosphate phosphatase.
    Biochim. Biophys. Acta 661 : 323-333 (1981). [PMID: 6271223]
  3. Woscholski, R. and Parker, P.J.
    Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
    In: Cockcroft, S. (Ed.) Biology of Phosphoinositides , Oxford University Press , Oxford , 2000 , 320-338

[EC created 1972, modified 2002]