EC - Inositol-phosphate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
inositol-phosphate phosphatase
Other names:
myo-inositol 1-phosphatase
myo-inositol monophosphatase
myo-inositol-1(or 4)-monophosphatase
myo-inositol-1(or 4)-phosphate phosphohydrolase
L-myo-inositol-1-phosphate phosphatase
inositol 1-phosphatase
inositol monophosphate phosphatase
inositol phosphatase
inositol-1(or 4)-monophosphatase
Systematic name:
myo-inositol-phosphate phosphohydrolase



Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols. Two isoforms are known [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00547
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008934 , GO:0052832 , GO:0052833 , GO:0052834
CAS Registry Number: 37184-63-7
UniProtKB/Swiss-Prot: (78) [show] [UniProt]


  1. Eisenberg, F., Jr.
    D-Myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis.
    J. Biol. Chem. 242 : 1375-1382 (1967). [PMID: 4290245]
  2. Gee, N.S., Ragan, C.I., Watling, K.J., Aspley, S., Jackson, R.G., Reid, G.G., Gani, D. and Shute, J.K.
    The purification and properties of myo-inositol monophosphatase from bovine brain.
    Biochem. J. 249 : 883-889 (1988). [PMID: 2833231]
  3. Hallcher, L.M. and Sherman, W.R.
    The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
    J. Biol. Chem. 255 : 10896-10901 (1980). [PMID: 6253491]
  4. Yoshikawa, T., Turner, G., Esterling, L.E., Sanders, A.R. and Detera-Wadleigh, S.D.
    A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.
    Mol. Psychiatry 2 : 393-397 (1997). [PMID: 9322233]
  5. Woscholski, R. and Parker, P.J.
    Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.
    In: Cockcroft, S. (Ed.) Biology of Phosphoinositides , Oxford University Press , Oxford , 2000 , 320-338
  6. Ackermann, K.E., Gish, B.G., Honchar, M.P. and Sherman, W.R.
    Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism.
    Biochem. J. 242 : 517-524 (1987). [PMID: 3036092]

[EC created 1972, modified 1990, modified 2002, modified 2004]