EC 3.1.3.25 - Inositol-phosphate phosphatase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.3.25
Names
Accepted name:
inositol-phosphate phosphatase
Other
names:
myo-inositol 1-phosphatase
myo-inositol monophosphatase
myo-inositol-1(or 4)-monophosphatase
myo-inositol-1(or 4)-phosphate phosphohydrolase
myo-inositol-1-phosphatase
L-myo-inositol-1-phosphate phosphatase
inositol 1-phosphatase
inositol monophosphate phosphatase
inositol phosphatase
inositol-1(or 4)-monophosphatase
myo-inositol monophosphatase
myo-inositol-1(or 4)-monophosphatase
myo-inositol-1(or 4)-phosphate phosphohydrolase
myo-inositol-1-phosphatase
L-myo-inositol-1-phosphate phosphatase
inositol 1-phosphatase
inositol monophosphate phosphatase
inositol phosphatase
inositol-1(or 4)-monophosphatase
Systematic name:
myo-inositol-phosphate phosphohydrolase
Reaction
- myo-inositol phosphate + H2O = myo-inositol + phosphate
Comments:
Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. It also acts on adenosine 2'-phosphate (but not the 3'- or 5'- phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols. Two isoforms are known [4].
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
DIAGRAM
,
DIAGRAM
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
UniPathway
Protein domains and families:
PROSITE:PDOC00547
CAS Registry Number:
37184-63-7
References
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D-Myoinositol 1-phosphate as product of cyclization of glucose 6-phosphate and substrate for a specific phosphatase in rat testis.J. Biol. Chem. 242 : 1375-1382 (1967). [PMID: 4290245]
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The purification and properties of myo-inositol monophosphatase from bovine brain.Biochem. J. 249 : 883-889 (1988). [PMID: 2833231]
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The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.J. Biol. Chem. 255 : 10896-10901 (1980). [PMID: 6253491]
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A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder.Mol. Psychiatry 2 : 393-397 (1997). [PMID: 9322233]
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Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates.In: Cockcroft, S. (Ed.) Biology of Phosphoinositides , Oxford University Press , Oxford , 2000 , 320-338
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Evidence that inositol 1-phosphate in brain of lithium-treated rats results mainly from phosphatidylinositol metabolism.Biochem. J. 242 : 517-524 (1987). [PMID: 3036092]
[EC 3.1.3.25 created 1972, modified 1990, modified 2002, modified 2004]