EC - Sucrose-phosphate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
sucrose-phosphate phosphatase
Other names:
sucrose 6-phosphate hydrolase
sucrose-phosphate hydrolase
sucrose-phosphate phosphohydrolase
sucrose phosphatase
sucrose-6-phosphate phosphatase
Systematic name:
sucrose-6F-phosphate phosphohydrolase




Requires Mg2+ for maximal activity [2]. This is the final step in the sucrose-biosynthesis pathway. The enzyme is highly specific for sucrose 6-phosphate, with fructose 6-phosphate unable to act as a substrate [2]. Belongs in the haloacid dehydrogenase (HAD) superfamily. The F in sucrose 6F-phosphate is used to indicate that the fructose residue of sucrose carries the substituent.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050307
CAS Registry Number: 9059-33-0
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Hawker, J.S. and Hatch, M.D.
    A specific sucrose phosphatase from plant tissues.
    Biochem. J. 99: 102-107 (1966). [PMID: 4290548]
  2. Lunn, J.E., Ashton, A.R., Hatch, M.D. and Heldt, H.W.
    Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants.
    Proc. Natl. Acad. Sci. USA 97: 12914-12919 (2000). [PMID: 11050182]
  3. Lunn, J.E. and MacRae, E.
    New complexities in the synthesis of sucrose.
    Curr. Opin. Plant Biol. 6: 208-214 (2003). [PMID: 12753969]
  4. Fieulaine, S., Lunn, J.E., Borel, F. and Ferrer, J.-L.
    The structure of a cyanobacterial sucrose-phosphatase reveals the sugar tongs that release free sucrose in the cell.
    Plant Cell 17: 2049-2058 (2005). [PMID: 15937230]

[EC created 1972, modified 2008]