EC - Protein-serine/threonine phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
protein-serine/threonine phosphatase
Other names:
3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase
Aspergillus awamori acid protein phosphatase
BCKDH phosphatase
HMG-CoA reductase phosphatase
branched-chain alpha-keto acid dehydrogenase phosphatase
casein phosphatase
phosphatase 2A
phosphatase 2B
phosphatase C-II
phosphatase H-II
phosphatase I
phosphatase IB
phosphatase II
phosphatase III
phosphatase IV
phosphatase SP
phosphopyruvate dehydrogenase phosphatase
phosphospectrin phosphatase
polycation modulated (PCM-) phosphatase
protein D phosphatase
protein phosphatase
protein phosphatase-1
protein phosphatase-2A
protein phosphatase-2B
protein phosphatase-2C
serine/threonine specific protein phosphatase
phosphoprotein phosphatase
Systematic name:
phosphoprotein phosphohydrolase



A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase (cf. EC protein-tyrosine-phosphatase). The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC phosphoamidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00115 , PROSITE:PDOC00785 , PROSITE:PDOC00792 , PROSITE:PDOC50969
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004721
CAS Registry Number: 9025-75-6
UniProtKB/Swiss-Prot: (961) [show] [UniProt]


  1. Deutscher, J., Kessler, U. and Hengstenberg, W.
    Streptococcal phosphoenolpyruvate: sugar phosphotransferase system: purification and characterization of a phosphoprotein phosphatase which hydrolyzes the phosphoryl bond in seryl-phosphorylated histidine-containing protein.
    J. Bacteriol. 163 : 1203-1209 (1985). [PMID: 2993239]
  2. Ingebritsen, T.S. and Cohen, P.
    The protein phosphatases involved in cellular regulation. 1. Classification and substrate specificities.
    Eur. J. Biochem. 132 : 255-261 (1983). [PMID: 6301824]
  3. Sundarajan, T.A. and Sarma, P.S.
    Substrate specificity of phosphoprotein phosphatase from spleen.
    Biochem. J. 71 : 537-544 (1959).
  4. Tonks, N.K. and Cohen, P.
    The protein phosphatases involved in cellular regulation. Identification of the inhibitor-2 phosphatases in rabbit skeletal muscle.
    Eur. J. Biochem. 145 : 65-70 (1984). [PMID: 6092084]

[EC created 1961, modified 1989, modified 2013]