EC - Alkaline phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
alkaline phosphatase
Other names:
alkaline phenyl phosphatase
alkaline phosphohydrolase
alkaline phosphomonoesterase
orthophosphoric-monoester phosphohydrolase (alkaline optimum)
Systematic name:
phosphate-monoester phosphohydrolase (alkaline optimum)




Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC inorganic diphosphatase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00113
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004035
CAS Registry Number: 9001-78-9
UniProtKB/Swiss-Prot: (40) [show] [UniProt]


  1. Engström, L.
    Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme.
    Biochim. Biophys. Acta 52 : 36-48 (1961). [PMID: 13890304]
  2. Harkness, D.R.
    Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme.
    Arch. Biochem. Biophys. 126 : 513-523 (1968). [PMID: 4970479]
  3. Malamy, M.H. and Horecker, B.L.
    Purification and crystallization of the alkaline phosphatase of Escherichia coli.
    Biochemistry 3 : 1893-1897 (1964). [PMID: 14269306]
  4. Morton, R.K.
    Alkaline phosphatase of milk. 2. Purification of the enzyme.
    Biochem. J. 55 : 795-800 (1953). [PMID: 13115375]
  5. Stadtman, T.C.
    Alkaline phosphatases.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 5 , Academic Press , New York , 1961 , 55-71

[EC created 1961]