EC 3.1.3.1 - Alkaline phosphatase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.3.1
Names
Accepted name:
alkaline phosphatase
Other
names:
alkaline phenyl phosphatase
alkaline phosphohydrolase
alkaline phosphomonoesterase
glycerophosphatase
orthophosphoric-monoester phosphohydrolase (alkaline optimum)
phosphomonoesterase
alkaline phosphohydrolase
alkaline phosphomonoesterase
glycerophosphatase
orthophosphoric-monoester phosphohydrolase (alkaline optimum)
phosphomonoesterase
Systematic name:
phosphate-monoester phosphohydrolase (alkaline optimum)
Reaction
- a phosphate monoester + H2O = an alcohol + phosphate
Cofactors
Comments:
Wide specificity. Also catalyses transphosphorylations. The human placental enzyme is a zinc protein. Some enzymes hydrolyse diphosphate (cf. EC 3.6.1.1 inorganic diphosphatase).
Links to other databases
Enzymes and pathways:
NC-IUBMB
,
BRENDA
,
ExplorEnz
,
ENZYME@ExPASy
,
KEGG
,
MetaCyc
,
NIST 74
,
UniPathway
Protein domains and families:
PROSITE:PDOC00113
Gene Ontology:
GO:0004035
CAS Registry Number:
9001-78-9
References
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Studies on calf-intestinal alkaline phosphatase. I. Chromatographic purification, microheterogeneity and some other properties of the purified enzyme.Biochim. Biophys. Acta 52 : 36-48 (1961). [PMID: 13890304]
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Studies on human placental alkaline phosphatase. II. Kinetic properties and studies on the apoenzyme.Arch. Biochem. Biophys. 126 : 513-523 (1968). [PMID: 4970479]
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Purification and crystallization of the alkaline phosphatase of Escherichia coli.Biochemistry 3 : 1893-1897 (1964). [PMID: 14269306]
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Alkaline phosphatase of milk. 2. Purification of the enzyme.Biochem. J. 55 : 795-800 (1953). [PMID: 13115375]
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Alkaline phosphatases.In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes , 2nd ed. vol. 5 , Academic Press , New York , 1961 , 55-71
[EC 3.1.3.1 created 1961]