EC - Ribonuclease H

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IntEnz Enzyme Nomenclature


Accepted name:
ribonuclease H
Other names:
RNA*DNA hybrid ribonucleotidohydrolase
RNase H
endoribonuclease H (calf thymus)
hybrid nuclease
hybrid ribonuclease
hybridase (ribonuclease H)
endoribonuclease H
calf thymus ribonuclease H
Systematic name:



Acts on RNA-DNA hybrids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50879
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004523
CAS Registry Number: 9050-76-4
UniProtKB/Swiss-Prot: (1000) [show] [UniProt]


  1. Haberkern, R.C. and Cantoni, G.L.
    Studies on a calf thymus ribonuclease specific for ribonucleic acid-deoxyribonucleic acid hybrids.
    Biochemistry 12 : 2389-2395 (1973). [PMID: 4709937]
  2. Stavrianopoulos, J.G. and Chargaff, E.
    Purification and properties of ribonuclease H of calf thymus.
    Proc. Natl. Acad. Sci. USA 70 : 1959-1963 (1973). [PMID: 4516197]

[EC created 1978, modified 2010]