EC - TRNase Z

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IntEnz Enzyme Nomenclature


Accepted name:
tRNase Z
Other names:
3 tRNase
3' tRNase
RNase Z
tRNA 3 endonuclease
Systematic name:



No cofactor requirements. An homologous enzyme to that found in Arabidopsis thaliana has been found in Methanococcus janaschii.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
CAS Registry Number: 98148-84-6
UniProtKB/Swiss-Prot: (293) [show] [UniProt]


  1. Schiffer, S., Rösch, S. and Marchfelder, A.
    Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes.
    EMBO J. 21: 2769-2777 (2002). [PMID: 12032089]
  2. Mayer, M., Schiffer, S. and Marchfelder, A.
    tRNA 3' processing in plants: nuclear and mitochondrial activities differ.
    Biochemistry 39: 2096-2105 (2000). [PMID: 10684660]
  3. Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A.
    The plant tRNA 3' processing enzyme has a broad substrate spectrum.
    Biochemistry 40: 8264-8272 (2001). [PMID: 11444972]
  4. Kunzmann, A., Brennicke, A. and Marchfelder, A.
    5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria.
    Proc. Natl. Acad. Sci. USA 95: 108-113 (1998). [PMID: 9419337]
  5. Mörl, M. and Marchfelder, A.
    The final cut. The importance of tRNA 3'-processing.
    EMBO Rep. 2: 17-20 (2001). [PMID: 11252717]
  6. Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M.
    A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima.
    J. Biol. Chem. 279: 15688-15697 (2004). [PMID: 14749326]
  7. Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M.
    A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
    Nucleic Acids Res. 31: 2272-2278 (2003). [PMID: 12711671]

[EC created 2002]