EC 184.108.40.206 - 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
IntEnz Enzyme Nomenclature
ydiL (gene name)
26309 [IUBMB]1,4-dihydroxy-2-naphthoyl-CoA1,4-dihydroxy-2-naphthoyl-CoAName origin: UniProt - CHECKED (C)Formula: C32H38N7O19P3S
Charge: -4ChEBI compound status: CHECKED (C)H2OH2OName origin: UniProt - CHECKED (C)Formula: H2O
Charge: 0ChEBI compound status: CHECKED (C)=1,4-dihydroxy-2-naphthoate1,4-dihydroxy-2-naphthoateName origin: UniProt - CHECKED (C)Formula: C11H7O4
Charge: -1ChEBI compound status: CHECKED (C)CoACoAName origin: UniProt - CHECKED (C)Formula: C21H32N7O16P3S
Charge: -4ChEBI compound status: CHECKED (C)
This enzyme participates in the synthesis of menaquinones , phylloquinone , as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates .
Links to other databases
1,4-naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis.Phytochemistry 15: 407-410 (1976).
Quantitative Assessment of Metabolic Flux by 13C NMR Analysis. Biosynthesis of Anthraquinones in Rubia tinctorum.J. Am. Chem. Soc. 121: 7469-7475 (1999).
A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.Proc. Natl. Acad. Sci. U.S.A. 106: 5599-5603 (2009). [PMID: 19321747]
Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.J. Bacteriol. 195: 2768-2775 (2013). [PMID: 23564174]
[EC 220.127.116.11 created 2010]