EC - Palmitoyl-[protein] hydrolase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
palmitoyl-[protein] hydrolase
Other names:
palmitoyl-(protein) hydrolase
palmitoyl-protein thioesterase
Systematic name:
palmitoyl-[protein] hydrolase



Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008474
UniProtKB/Swiss-Prot: (76) [show] [UniProt]


  1. Camp, L.A., Hofmann, S.L.
    Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate.
    Methods Enzymol. 250 : 336-347 (1995). [PMID: 7651163]
  2. Schriner, J.E., Yi, W., Hofmann, S.L.
    cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis.
    Genomics, 34 : 317-322 (1996). [PMID: 8786130]
  3. Verkruyse, L.A., Hofmann, S.L.
    Lysosomal targeting of palmitoyl-protein thioesterase.
    J. Biol. Chem. 271 : 15831-15836 (1996). [PMID: 8663305]

[EC created 1999]