EC - Palmitoyl-CoA hydrolase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
palmitoyl-CoA hydrolase
Other names:
fatty acyl thioesterase I
long-chain fatty-acyl-CoA hydrolase
palmitoyl coenzyme A hydrolase
palmitoyl thioesterase
palmitoyl-CoA deacylase
palmityl thioesterase
palmityl thioesterase I
palmityl-CoA deacylase
Systematic name:
palmitoyl-CoA hydrolase



Also hydrolyses CoA thioesters of other long-chain fatty acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102991 , GO:0016290
CAS Registry Number: 9025-87-0
UniProtKB/Swiss-Prot: (75) [show] [UniProt]


  1. Barnes, E.M., Jr. and Wakil, S.J.
    Studies on the mechanism of fatty acid synthesis. XIX. Preparation and general properties of palmityl thioesterase.
    J. Biol. Chem. 243 : 2955-2962 (1968). [PMID: 4871199]
  2. Berge, R.K. and Farstad, M.
    Long-chain fatty acyl-CoA hydrolase from rat liver mitochondria.
    Methods Enzymol. 71 : 234-242 (1981). [PMID: 6116156]
  3. Miyazawa, S., Furuta, S. and Hashimoto, T.
    Induction of a novel long-chain acyl-CoA hydrolase in rat liver by administration of peroxisome proliferators.
    Eur. J. Biochem. 117 : 425-430 (1981). [PMID: 6115749]
  4. Srere, P.A., Seubert, W. and Lynen, F.
    Palmityl coenzyme A deacylase.
    Biochim. Biophys. Acta 33 : 313-319 (1959). [PMID: 13670899]
  5. Yabusaki, K.K. and Ballou, C.E.
    Long-chain fatty acyl-CoA thioesterases from Mycobacterium smegmatis.
    Methods Enzymol. 71 : 242-246 (1981).

[EC created 1961]