EC - Exoribonuclease II

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IntEnz Enzyme Nomenclature


Accepted name:
exoribonuclease II
Other names:
Escherichia coli exo-RNase II
BN ribonuclease
RNase II
ribonuclease II
ribonuclease Q
Systematic name:



Preference for single-stranded RNA. The enzyme processes 3'-terminal extra-nucleotides of monomeric tRNA precursors, following the action of EC ribonuclease P. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008859
CAS Registry Number: 37288-24-7
UniProtKB/Swiss-Prot: (121) [show] [UniProt]


  1. Nossal, N.G. and Singer, M.
    The processive degradation of individual polyribonucleotide chains. I. Escherichia coli ribonuclease II.
    J. Biol. Chem. 243: 913-922 (1968). [PMID: 4867942]
  2. Schmidt, F.J. and McClain, W.H.
    An Escherichia coli ribonuclease which removes an extra nucleotide from a biosynthetic intermediate of bacteriophage T4 proline transfer RNA.
    Nucleic Acids Res. 5: 4129-4139 (1978). [PMID: 364422]
  3. Shimura, Y., Sakano, H. and Nagawa, F.
    Specific ribonucleases involved in processing of tRNA precursors of Escherichia coli. Partial purification and some properties.
    Eur. J. Biochem. 86: 267-281 (1978). [PMID: 350582]
  4. Sporn, M.B., Lazarus, H.M. Smith, J.M. and Henderson, W.R.
    Studies on nuclear exoribonucleases. 3. Isolation and properties of the enzyme from normal and malignant tissues of the mouse.
    Biochemistry 8: 1698-1706 (1969). [PMID: 5805304]

[EC created 1972 as EC, transferred 1978 to EC]