EC - Exodeoxyribonuclease V

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IntEnz Enzyme Nomenclature


Accepted name:
exodeoxyribonuclease V
Other names:
E. coli exonuclease V
Escherichia coli exonuclease V
RecBC deoxyribonuclease
exonuclease V
gene recBC DNase
gene recBC endoenzyme
gene recBCD enzymes
Systematic name:



Preference for double-stranded DNA. Possesses DNA-dependent ATPase activity. Acts endonucleolytically on single-stranded circular DNA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008854
UniProtKB/Swiss-Prot: (28) [show] [UniProt]


  1. Eichler, D.C. and Lehman, I.R.
    On the role of ATP in phosphodiester bond hydrolysis catalyzed by the recBC deoxyribonuclease of Escherichia coli.
    J. Biol. Chem. 252: 499-503 (1977). [PMID: 319095]
  2. Goldmark, P.J. and Liun, S.
    Purification and properties of the recBC DNase of Escherichia coli K-12.
    J. Biol. Chem. 247: 1849-1860 (1972). [PMID: 4552016]
  3. Oishi, M.
    An ATP-dependent deoxyribonuclease from Escherichia coli with a possible role in genetic recombination.
    Proc. Natl. Acad. Sci. USA 64: 1292-1299 (1969). [PMID: 4916924]
  4. Wright, M., Buttin, G. and Hurwitz, J.
    The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes.
    J. Biol. Chem. 246: 6543-6555 (1971). [PMID: 4332130]

[EC created 1978]