EC - Exodeoxyribonuclease I

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IntEnz Enzyme Nomenclature


Accepted name:
exodeoxyribonuclease I
Other names:
E. coli exonuclease I
Escherichia coli exonuclease I
exonuclease I
Systematic name:



Preference for single-stranded DNA. The Escherichia coli enzyme hydrolyses glucosylated DNA. Formerly EC

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008852
UniProtKB/Swiss-Prot: (50) [show] [UniProt]


  1. Blakesley, R.W., Dodgson, J.B., Nes, I.F. and Wells, R.D.
    Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius.
    J. Biol. Chem. 252: 7300-7306 (1977). [PMID: 71298]
  2. Kelley, R.B., Atkinson, M.R., Huberman, J.A. and Kornberg, A.
    Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli.
    Nature 224: 495-501 (1969).
  3. Lehman, I.R. and Nussbaum, A.L.
    The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase).
    J. Biol. Chem. 239: 2628-2636 (1964).

[EC created 1972 as EC, transferred 1978 to EC]