IntEnz

EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase

IntEnz Enzyme Nomenclature
EC 3.1.1.98

Names

Reaction

• 45340 [IUBMB]
  [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine

  [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine

  GENERIC:11171

  Is ROOT: no
  ROOT compound: GENERIC:11169

  Number of residues: 1

  O-[(9Z)-hexadecenoyl]serine residue O-[(9Z)-hexadecenoyl]serine residue Name origin: UniProt - CHECKED (C) CHEBI:85189 Formula: C19H33NO3 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  (9Z)-hexadecenoate

  (9Z)-hexadecenoate

  Name origin: UniProt - CHECKED (C)

  CHEBI:32372

  Formula: C16H29O2
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  [Wnt protein]-L-serine

  [Wnt protein]-L-serine

  GENERIC:11170

  Is ROOT: no
  ROOT compound: GENERIC:11169

  Number of residues: 1

  L-serine residue L-serine residue Name origin: UniProt - CHECKED (C) CHEBI:29999 Formula: C3H5NO2 Charge: 0 Position: undefined ChEBI compound status: CHECKED (C)

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Comments:

The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.

Links to other databases

References

1. Kakugawa, S., Langton, P. F., Zebisch, M., Howell, S. A., Chang, T. H., Liu, Y., Feizi, T., Bineva, G., O'Reilly, N., Snijders, A. P., Jones, E. Y., Vincent, J. P.
   Notum deacylates Wnt proteins to suppress signalling activity.
   Nature 519 : 187-192 (2015). [PMID: 25731175]

[EC 3.1.1.98 created 2015]