EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 3.1.1.98
Names
Accepted name:
[Wnt protein] O-palmitoleoyl-L-serine hydrolase
Other
name:
Notum
Systematic name:
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase
Reaction
- Wnt-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = Wnt-L-serine + (9Z)-hexadec-9-enoate
Comments:
The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.
Links to other databases
UniProtKB/Swiss-Prot:
NOT1A_DANRE
NOT1P_XENLA
NOT1_XENLA
NOTU2_XENLA
NOTUM-2_MOUSE
NOTUM_DROME
NOTUM_HUMAN
NOTUM_MOUSE
NOTUM_SCHMD
References
-
Notum deacylates Wnt proteins to suppress signalling activity.Nature 519 : 187-192 (2015). [PMID: 25731175]
[EC 3.1.1.98 created 2015]