EC 3.1.1.98 - [Wnt protein] O-palmitoleoyl-L-serine hydrolase

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IntEnz Enzyme Nomenclature
EC 3.1.1.98

Names

Accepted name:
[Wnt protein] O-palmitoleoyl-L-serine hydrolase
Other name:
Notum
Systematic name:
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine acylhydrolase

Reaction

Comments:

The enzyme removes the palmitoleate modification that is introduced to specific L-serine residues in Wnt proteins by EC 2.3.1.250, [Wnt protein]-O-palmitoleoyl transferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Kakugawa, S., Langton, P. F., Zebisch, M., Howell, S. A., Chang, T. H., Liu, Y., Feizi, T., Bineva, G., O'Reilly, N., Snijders, A. P., Jones, E. Y., Vincent, J. P.
    Notum deacylates Wnt proteins to suppress signalling activity.
    Nature 519 : 187-192 (2015). [PMID: 25731175]

[EC 3.1.1.98 created 2015]