EC 3.1.1.95 - Aclacinomycin methylesterase

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IntEnz Enzyme Nomenclature
EC 3.1.1.95

Names

Accepted name:
aclacinomycin methylesterase
Other names:
RdmC
aclacinomycin methyl esterase
Systematic name:
aclacinomycin T acylhydrolase

Reaction

Comments:

The enzyme is involved in the modification of the aklavinone skeleton in the biosynthesis of anthracyclines in Streptomyces species.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102542 , GO:0102530 , GO:0102543
UniProtKB/Swiss-Prot:

References

  1. Wang, Y., Niemi, J., Airas, K., Ylihonko, K., Hakala, J., Mantsala, P.
    Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens.
    Biochim. Biophys. Acta 1480 : 191-200 (2000). [PMID: 11004563]
  2. Jansson, A., Niemi, J., Mantsala, P., Schneider, G.
    Crystal structure of aclacinomycin methylesterase with bound product analogues: implications for anthracycline recognition and mechanism.
    J. Biol. Chem. 278 : 39006-39013 (2003). [PMID: 12878604]

[EC 3.1.1.95 created 2013]