EC - Pyrethroid hydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
pyrethroid hydrolase
Other names:
pyrethroid-hydrolyzing carboxylesterase
pyrethroid-hydrolysing esterase
pyrethroid-hydrolyzing esterase
pyrethroid-selective esterase
pyrethroid-cleaving enzyme
Systematic name:
pyrethroid-ester hydrolase



The enzyme is involved in degradation of pyrethroid pesticides. The enzymes from Sphingobium sp., Klebsiella sp. and Aspergillus niger hydrolyse cis-permethrin at approximately equal rate to trans-permethrin [1-3]. The enzyme from mouse hydrolyses trans-permethrin at a rate about 22-fold higher than cis-permethrin [4].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102209


  1. Wang, B. Z., Guo, P., Hang, B. J., Li, L., He, J., Li, S. P.
    Cloning of a novel pyrethroid-hydrolyzing carboxylesterase gene from Sphingobium sp. strain JZ-1 and characterization of the gene product.
    Appl. Environ. Microbiol. 75 : 5496-5500 (2009). [PMID: 19581484]
  2. Wu, P. C., Liu, Y. H., Wang, Z. Y., Zhang, X. Y., Li, H., Liang, W. Q., Luo, N., Hu, J. M., Lu, J. Q., Luan, T. G., Cao, L. X.
    Molecular cloning, purification, and biochemical characterization of a novel pyrethroid-hydrolyzing esterase from Klebsiella sp. strain ZD112.
    J. Agric. Food Chem. 54 : 836-842 (2006). [PMID: 16448191]
  3. Liang, W. Q., Wang, Z. Y., Li, H., Wu, P. C., Hu, J. M., Luo, N., Cao, L. X., Liu, Y. H.
    Purification and characterization of a novel pyrethroid hydrolase from Aspergillus niger ZD11.
    J. Agric. Food Chem. 53 : 7415-7420 (2005). [PMID: 16159167]
  4. Stok, J. E., Huang, H., Jones, P. D., Wheelock, C. E., Morisseau, C., Hammock, B. D.
    Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes.
    J. Biol. Chem. 279 : 29863-29869 (2004). [PMID: 15123619]
  5. Maloney, S. E., Maule, A., Smith, A. R.
    Purification and preliminary characterization of permethrinase from a pyrethroid-transforming strain of Bacillus cereus.
    Appl. Environ. Microbiol. 59 : 2007-2013 (1993). [PMID: 8357241]
  6. Guo, P., Wang, B., Hang, B., Li, L., Ali, W., He, J. and Li, S.
    Pyrethroid-degrading Sphingobium sp. JZ-2 and the purification and characterization of a novel pyrethroid hydrolase.
    Int. Biodeter. Biodegrad. 63 : 1107-1112 (2009).

[EC created 2011]