EC - Cocaine esterase

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IntEnz Enzyme Nomenclature


Accepted name:
cocaine esterase
Other names:
human carboxylesterase 2
Systematic name:
cocaine benzoylhydrolase



Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy [2,3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB


  1. Gao, D., Narasimhan, D. L., Macdonald, J., Brim, R., Ko, M. C., Landry, D. W., Woods, J. H., Sunahara, R. K., Zhan, C. G.
    Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
    Mol. Pharmacol. 75 : 318-323 (2009). [PMID: 18987161]
  2. Bresler, M. M., Rosser, S. J., Basran, A., Bruce, N. C.
    Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1.
    Appl. Environ. Microbiol. 66 : 904-908 (2000). [PMID: 10698749]
  3. Britt, A. J., Bruce, N. C., Lowe, C. R.
    Identification of a cocaine esterase in a strain of Pseudomonas maltophilia.
    J. Bacteriol. 174 : 2087-2094 (1992). [PMID: 1551831]
  4. Larsen, N. A., Turner, J. M., Stevens, J., Rosser, S. J., Basran, A., Lerner, R. A., Bruce, N. C., Wilson, I. A.
    Crystal structure of a bacterial cocaine esterase.
    Nat. Struct. Biol. 9 : 17-21 (2002). [PMID: 11742345]
  5. Pindel, E. V., Kedishvili, N. Y., Abraham, T. L., Brzezinski, M. R., Zhang, J., Dean, R. A., Bosron, W. F.
    Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.
    J. Biol. Chem. 272 : 14769-14775 (1997). [PMID: 9169443]

[EC created 2010]