EC - Acetylcholinesterase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
acetylcholine hydrolase
choline esterase I
true cholinesterase
Systematic name:
acetylcholine acetylhydrolase



Acts on a variety of acetic esters; also catalyses transacetylations.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003990
CAS Registry Number: 9000-81-1
UniProtKB/Swiss-Prot: (37) [show] [UniProt]


  1. Augustinsson, K.-B.
    Cholinesterases. A study in comparative enzymology.
    Acta Physiol. Scand. 15 (1948).
  2. Bergmann, F., Rimon, S. and Segal, R.
    Effect of pH on the activity of eel esterase towards different substrates.
    Biochem. J. 68 : 493-499 (1958). [PMID: 13522650]
  3. Cilliv, G. and Ozand, P.T.
    Human erythrocyte acetylcholinesterase purification, properties and kinetic behavior.
    Biochim. Biophys. Acta 284 : 136-156 (1972). [PMID: 5073758]
  4. Leuzinger, W., Baker, A.L. and Cauvin, E.
    Acetylcholinesterase. II. Crystallization, absorption spectra, isoionic point.
    Proc. Natl. Acad. Sci. USA 59 : 620-623 (1968). [PMID: 5238989]
  5. Nachmansohn, D. and Wilson, I.B.
    The enzymic hydrolysis and synthesis of acetylcholine.
    Adv. Enzymol. Relat. Subj. Biochem. 12 : 259-339 (1951). [PMID: 14885021]
  6. Zittle, C.A., DellaMonica, E.S., Custer, J.H. and Krikorian, R.
    Purification of human red cell acetylcholinesterase by electrophoresis, ultracentrifugation and gradient extraction.
    Arch. Biochem. Biophys. 56 : 469-475 (1955). [PMID: 14377597]

[EC created 1961]