EC - 2-pyrone-4,6-dicarboxylate lactonase

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IntEnz Enzyme Nomenclature


Accepted name:
2-pyrone-4,6-dicarboxylate lactonase
Other names:
2-pyrone-4,6-dicarboxylate hydrolase
2-pyrone-4,6-dicarboxylate lactonohydrolase
Systematic name:
2-oxo-2H-pyran-4,6-dicarboxylate lactonohydrolase



The product is most likely the keto-form of 4-oxalmesaconate (shown) [1,2]. It can be converted to the enol-form, 4-hydroxybuta-1,3-diene-1,2,4-trioate, either spontaneously or by EC, 4-oxalomesaconate tautomerase [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047554
CAS Registry Number: 84177-55-9


  1. Kersten, P.J., Dagley, S., Whittaker, J.W., Arciero, D.M. and Lipscomb, J.D.
    2-Pyrone-4,6-dicarboxylic acid, a catabolite of gallic acids in Pseudomonas species.
    J. Bacteriol. 152 : 1154-1162 (1982). [PMID: 7142106]
  2. Maruyama, K.
    Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase.
    J. Biochem. (Tokyo) 93 : 557-565 (1983). [PMID: 6841353]
  3. Nogales, J., Canales, A., Jimenez-Barbero, J., Serra, B., Pingarron, J. M., Garcia, J. L., Diaz, E.
    Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
    Mol. Microbiol. 79 : 359-374 (2011). [PMID: 21219457]

[EC created 1986]