EC - Sialate O-acetylesterase

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IntEnz Enzyme Nomenclature


Accepted name:
sialate O-acetylesterase
Other names:
N-acetylneuraminate acetyltransferase
sialate 9(4)-O-acetylesterase
Systematic name:
N-acyl-O-acetylneuraminate O-acetylhydrolase



Acts on free and glycosidically bound N-acetyl- or N-glycoloyl-neuraminic acid; acts mainly on the 4-O- and 9-O-acetyl groups. Also acts on some other O-acetyl esters, both cyclic and acyclic compounds, which are not sialic acids.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0001681
CAS Registry Number: 89400-31-7
UniProtKB/Swiss-Prot: (48) [show] [UniProt]


  1. Garcia-Sastre, A., Villar, E., Manuguerra, J.C., Hannoun, C. and Cabezas, J.A.
    Activity of influenza C virus O-acetylesterase with O-acetyl-containing compounds.
    Biochem. J. 273: 435-441 (1991). [PMID: 1991039]
  2. Shukla, A.K. and Schauer, R.
    High performance liquid chromatography of enzymes of sialic acid metabolism.
    Hoppe-Seyler's Z. Physiol. Chem. 363: 1039-1040 (1982).

[EC created 1984]