EC 3.1.1.51 - Phorbol-diester hydrolase

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IntEnz Enzyme Nomenclature
EC 3.1.1.51

Names

Accepted name:
phorbol-diester hydrolase
Other names:
PDEH
diacylphorbate 12-hydrolase
phorbol-12,13-diester 12-ester hydrolase
Systematic name:
12,13-diacylphorbate 12-acylhydrolase

Reaction

Comments:

Hydrolyses the 12-ester bond in a variety of 12,13-diacylphorbols (phorbol is a diterpenoid); this reaction inactivates the tumour promotor 12-O-tetradecanoylphorbol-13-acetate from croton oil.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050181

References

  1. Shoyab, M., Warren, T.C. and Todaro, G.J.
    Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver.
    J. Biol. Chem. 256: 12529-12534 (1981). [PMID: 6946062]

[EC 3.1.1.51 created 1984]