EC 3.1.1.5 - Lysophospholipase
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IntEnz Enzyme Nomenclature
EC 3.1.1.5
Names
Accepted name:
lysophospholipase
Other
names:
lecithinase B
lecitholipase
lysolecithinase
lysophopholipase L2
lysophosphatidase
lysophosphatidylcholine hydrolase
lysophospholipase A1
phosphatidase B
phospholipase B
lecitholipase
lysolecithinase
lysophopholipase L2
lysophosphatidase
lysophosphatidylcholine hydrolase
lysophospholipase A1
phosphatidase B
phospholipase B
Systematic name:
2-lysophosphatidylcholine acylhydrolase
Reaction
- 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate
Links to other databases
Protein domains and families:
PROSITE:PDOC00279
Gene Ontology:
GO:0004622
,
GO:0102545
CAS Registry Number:
9001-85-8
References
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Possible identity of lysolecithin acyl-hydrolase with lysolecithin-lysolecithin acyl-transferase in rat-lung soluble fraction.Biochim. Biophys. Acta 369 : 361-370 (1974).
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The enzymic cleavage of lecithin and lysolecithin.Biochem. Z. 261 : 275-302 (1933).
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Studies on the hydrolysis of lecithin by Penicillium notatum phospholipase B preparation.Biochem. J. 70 : 559-570 (1958).
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The preparation and properties of a lysophospholipase from Penicillium notatum.J. Biol. Chem. 173 : 705-714 (1948).
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Purification and properties of a lysolecithinase from pancreas.Biochem. J. 53 : 663-666 (1953). [PMID: 13032127]
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Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas.Biochim. Biophys. Acta 296 : 94-104 (1973). [PMID: 4693514]
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Lysophospholipase-transacylase from rat lung.Methods Enzymol. 71 : 513-521 (1981). [PMID: 7278668]
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Human neuropathy target esterase catalyzes hydrolysis of membrane lipids.J. Biol. Chem. 277 : 20942-20948 (2002). [PMID: 11927584]
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Evidence that mouse brain neuropathy target esterase is a lysophospholipase.Proc. Natl. Acad. Sci. USA 100 : 7983-7987 (2003). [PMID: 12805562]
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Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.Biochem. J. 332 : 1-4 (1998). [PMID: 9576844]
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Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.Nat. Genet. 33 : 477-485 (2003). [PMID: 12640454]
[EC 3.1.1.5 created 1961, modified 1976, modified 1983]