EC - Lysophospholipase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
lecithinase B
lysophopholipase L2
lysophosphatidylcholine hydrolase
lysophospholipase A1
phosphatidase B
phospholipase B
Systematic name:
2-lysophosphatidylcholine acylhydrolase


Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00279
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004622 , GO:0102545
CAS Registry Number: 9001-85-8
UniProtKB/Swiss-Prot: (162) [show] [UniProt]


  1. Abe, M., Ohno, K. and Sato, R.
    Possible identity of lysolecithin acyl-hydrolase with lysolecithin-lysolecithin acyl-transferase in rat-lung soluble fraction.
    Biochim. Biophys. Acta 369 : 361-370 (1974).
  2. Contardi, A. and Ercoli, A.
    The enzymic cleavage of lecithin and lysolecithin.
    Biochem. Z. 261 : 275-302 (1933).
  3. Dawson, R.M.C.
    Studies on the hydrolysis of lecithin by Penicillium notatum phospholipase B preparation.
    Biochem. J. 70 : 559-570 (1958).
  4. Fairbairn, D.
    The preparation and properties of a lysophospholipase from Penicillium notatum.
    J. Biol. Chem. 173 : 705-714 (1948).
  5. Shapiro, B.
    Purification and properties of a lysolecithinase from pancreas.
    Biochem. J. 53 : 663-666 (1953). [PMID: 13032127]
  6. van den Bosch, H., Aarsman, A.J., De Jong, J.G.N. and van Deenen, L.L.M.
    Studies on lysophospholipases. I. Purification and some properties of a lysophospholipase from beef pancreas.
    Biochim. Biophys. Acta 296 : 94-104 (1973). [PMID: 4693514]
  7. van den Bosch, H., Vianen, G.M. and van Heusden, G.P.H.
    Lysophospholipase-transacylase from rat lung.
    Methods Enzymol. 71 : 513-521 (1981). [PMID: 7278668]
  8. van Tienhoven, M., Atkins, J., Li, Y. and Glynn, P.
    Human neuropathy target esterase catalyzes hydrolysis of membrane lipids.
    J. Biol. Chem. 277 : 20942-20948 (2002). [PMID: 11927584]
  9. Quistad, G.B., Barlow, C., Winrow, C.J., Sparks, S.E. and Casida, J.E.
    Evidence that mouse brain neuropathy target esterase is a lysophospholipase.
    Proc. Natl. Acad. Sci. USA 100 : 7983-7987 (2003). [PMID: 12805562]
  10. Lush, M.J., Li, Y., Read, D.J., Willis, A.C. and Glynn, P.
    Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man.
    Biochem. J. 332 : 1-4 (1998). [PMID: 9576844]
  11. Winrow, C.J., Hemming, M.L., Allen, D.M., Quistad, G.B., Casida, J.E. and Barlow, C.
    Loss of neuropathy target esterase in mice links organophosphate exposure to hyperactivity.
    Nat. Genet. 33 : 477-485 (2003). [PMID: 12640454]

[EC created 1961, modified 1976, modified 1983]