EC - Phospholipase A2

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
phospholipase A2
Other names:
lecithinase A
phospholipase A
phospholipase A2
Systematic name:
phosphatidylcholine 2-acylhydrolase




Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position. Requires Ca2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00109
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004623
CAS Registry Number: 9001-84-7
UniProtKB/Swiss-Prot: (645) [show] [UniProt]


  1. Doery, H.M. and Pearson, J.E.
    Haemolysins in venoms of Australian snakes. Observations on the haemolysins of the venoms of some Australian snakes and the separation of phospholipase A from the venom of Pseudechis porphyriacus.
    Biochem. J. 78 : 820-827 (1961). [PMID: 13723433]
  2. Fraenkel-Conrat, H. and Fraenkel-Conrat, J.
    Inactivation of crotoxin by group-specific reagents.
    Biochim. Biophys. Acta 5 : 98-104 (1950). [PMID: 15433984]
  3. Hanahan, D.J., Brockerhoff, H. and Barron, E.J.
    The site of attack of phospholipase (lecithinase) A on lecithin: a re-evaluation. Position of fatty acids on lecithins and triglycerides.
    J. Biol. Chem. 235 : 1917-1923 (1960). [PMID: 14399412]
  4. Moore, J.H. and Williams, D.L.
    Some observations on the specificity of phospholipase A.
    Biochim. Biophys. Acta 84 : 41-54 (1964). [PMID: 14124755]
  5. Saito, K. and Hanahan, D.J.
    A study of the purification and properties of the phospholipase A of Crotalus adamanteus venom.
    Biochemistry 1 : 521-532 (1962). [PMID: 14496116]
  6. van den Bosch, H.
    Intracellular phospholipases A.
    Biochim. Biophys. Acta 604 : 191-246 (1980). [PMID: 6252969]

[EC created 1961, modified 1976, modified 1983]