EC - Lipoprotein lipase

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IntEnz Enzyme Nomenclature


Accepted name:
lipoprotein lipase
Other names:
clearing factor lipase
diacylglycerol hydrolase
diacylglycerol lipase
diglyceride lipase
lipemia-clearing factor
postheparin esterase
postheparin lipase
Systematic name:
triacylglycerol acylhydrolase (lipoprotein-dependent)



Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles (VLDL). Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride → 1,2-diglyceride → 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00110
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004465
CAS Registry Number: 9004-02-8
UniProtKB/Swiss-Prot: (11) [show] [UniProt]


  1. Egelrud, T. and Olivecrona, T.
    Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.
    Biochim. Biophys. Acta 306 : 115-127 (1973). [PMID: 4703566]
  2. Fielding, C.J.
    Human lipoprotein lipase. I. Purification and substrate specificity.
    Biochim. Biophys. Acta 206 : 109-117 (1970). [PMID: 5441398]
  3. Greten, H., Levy, R.I., Fales, H. and Fredrickson, D.S.
    Hydrolysis of diglyceride and glyceryl monoester diethers with lipoprotein lipase.
    Biochim. Biophys. Acta 210 : 39-45 (1970). [PMID: 5466051]
  4. Morley, N. and Kuksis, A.
    Positional specificity of lipoprotein lipase.
    J. Biol. Chem. 247 : 6389-6393 (1972). [PMID: 5076762]
  5. Nilsson-Ehle, P., Belfrage, P. and Borgström, B.
    Purified human lipoprotein lipase: positional specificity.
    Biochim. Biophys. Acta 248 : 114-120 (1971). [PMID: 5168777]
  6. Santamarina-Fojo, S., Gonzalez-Navarro, H., Freeman, L., Wagner, E., Nong, Z.
    Hepatic lipase, lipoprotein metabolism, and atherogenesis.
    Arterioscler. Thromb. Vasc. Biol. 24 : 1750-1754 (2004). [PMID: 15284087]

[EC created 1972, modified 1976]