IntEnz

EC 3.1.1.32 - Phospholipase A₁

IntEnz Enzyme Nomenclature
EC 3.1.1.32

Names

Reaction

• 18689 [IUBMB]
  a 1,2-diacyl-sn-glycero-3-phosphocholine

  a 1,2-diacyl-sn-glycero-3-phosphocholine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57643

  Formula: C10H18NO8PR2
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  H₂O

  H2O

  Name origin: UniProt - CHECKED (C)

  CHEBI:15377

  Formula: H2O
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  =

  a 2-acyl-sn-glycero-3-phosphocholine

  a 2-acyl-sn-glycero-3-phosphocholine

  Name origin: UniProt - CHECKED (C)

  CHEBI:57875

  Formula: C9H19NO7PR
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  a fatty acid

  a fatty acid

  Name origin: UniProt - CHECKED (C)

  CHEBI:28868

  Formula: CO2R
  Charge: -1

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Cofactor

• Ca²⁺

Comments:

This enzyme has a much broader specificity than EC 3.1.1.4 phospholipase A₂. Requires Ca²⁺.

Links to other databases

References

1. Gatt, S.
   Purification and properties of phospholipase A-1 from rat and calf brain.
   Biochim. Biophys. Acta 159: 304-316 (1968). [PMID: 5657461]
2. Scandella, C.J. and Kornberg, A.
   A membrane-bound phospholipase A₁ purified from Escherichia coli.
   Biochemistry 10: 4447-4456 (1971). [PMID: 4946924]
3. van den Bosch, H.
   Intracellular phospholipases A.
   Biochim. Biophys. Acta 604: 191-246 (1980). [PMID: 6252969]
4. van den Bosch, H., Aarsman, A.J. and van Deenen, L.L.M.
   Isolation and properties of a phospholipase A₁ activity from beef pancreas.
   Biochim. Biophys. Acta 348: 197-209 (1974). [PMID: 4858811]

[EC 3.1.1.32 created 1972, modified 1976]