EC - Sterol esterase

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IntEnz Enzyme Nomenclature


Accepted name:
sterol esterase
Other names:
acylcholesterol lipase
cholesterol ester hydrolase
cholesterol esterase
cholesteryl ester hydrolase
cholesteryl ester synthase
cholesteryl esterase
sterol ester hydrolase
triterpenol esterase
cholesterol ester synthase
Systematic name:
steryl-ester acylhydrolase



A group of enzymes of broad specificity, acting on esters of sterols and long-chain fatty acids, that may also bring about the esterification of sterols. Activated by bile salts.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004771
CAS Registry Number: 9026-00-0
UniProtKB/Swiss-Prot: (14) [show] [UniProt]


  1. Hyun, J., Kothari, H., Herm, E., Mortenson, J., Treadwell, C.R. and Vahouny, G.V.
    Purification and properties of pancreatic juice cholesterol esterase.
    J. Biol. Chem. 244 : 1937-1945 (1969). [PMID: 5780846]
  2. Okawa, Y. and Yamaguchi, T.
    Studies on sterol-ester hydrolase from Fusarium oxysporum. I. Partial purification and properties.
    J. Biochem. (Tokyo) 81 : 1209-1215 (1977). [PMID: 19426]
  3. Vahouny, G.V. and Tradwell, C.R.
    Enzymatic synthesis and hydrolysis of cholesterol esters.
    Methods Biochem. Anal. 16 : 219-272 (1968). [PMID: 4877146]
  4. Warnaar, F.
    Triterpene ester synthesis in latex of Euphorbia species.
    Phytochemistry 26 : 2715-2721 (1987).

[EC created 1961, modified 1990]