EC - Phosphatidylserine sn-1 acylhydrolase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphatidylserine sn-1 acylhydrolase
Other names:
phosphatidylserine-specific phospholipase A1
Systematic name:
3-sn-phosphatidyl-L-serine sn-1 acylhydrolase



The enzyme, which has described from mammals, is specific for phosphatidylserine and 2-lysophosphatidylserine, and does not act on phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid or phosphatidylinositol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB


  1. Sato, T., Aoki, J., Nagai, Y., Dohmae, N., Takio, K., Doi, T., Arai, H., Inoue, K.
    Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family.
    J. Biol. Chem. 272 : 2192-2198 (1997). [PMID: 8999922]
  2. Nagai, Y., Aoki, J., Sato, T., Amano, K., Matsuda, Y., Arai, H., Inoue, K.
    An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.
    J. Biol. Chem. 274 : 11053-11059 (1999). [PMID: 10196188]
  3. Hosono, H., Aoki, J., Nagai, Y., Bandoh, K., Ishida, M., Taguchi, R., Arai, H., Inoue, K.
    Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine.
    J. Biol. Chem. 276 : 29664-29670 (2001). [PMID: 11395520]
  4. Aoki, J., Nagai, Y., Hosono, H., Inoue, K., Arai, H.
    Structure and function of phosphatidylserine-specific phospholipase A1.
    Biochim. Biophys. Acta 1582 : 26-32 (2002). [PMID: 12069807]

[EC created 2019]