EC 2.8.4.2 - Arsenate-mycothiol transferase

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IntEnz Enzyme Nomenclature
EC 2.8.4.2

Names

Accepted name:
arsenate-mycothiol transferase
Other names:
ArsC1
ArsC2
mycothiol:arsenate transferase
Systematic name:
mycothiol:arsenate S-arsenotransferase

Reaction

Comments:

Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0102100
UniProtKB/Swiss-Prot:

References

  1. Ordonez, E., Van Belle, K., Roos, G., De Galan, S., Letek, M., Gil, J. A., Wyns, L., Mateos, L. M., Messens, J.
    Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
    J. Biol. Chem. 284: 15107-15116 (2009). [PMID: 19286650]

[EC 2.8.4.2.created 2010]